Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701–negative recipients

Flight and tunnel test results of the MDC mechanical jet noise suppressor nozzle

The flight and wind tunnel tests to determine the acoustic and performance effects of a mechanical jet noise suppressor nozzle mounted on a Viper engine of an HS-125 airplane are discussed. Flyover noise measurements were made with microphones mounted on top of a 137.5 m bridge tower. Seven nozzle configurations including two references nozzles, two suppressors, and three ejector inlets were tested. The suppressor nozzle of interest for an advanced supersonic transport, the suppressor/treated ejector, achieved a measured noise reduction of 14 EPNdB relative to a conventional conical reference nozzle at the highest pressure ratio tested (approximately 2.5). The unique engine nacelle, flight hardware, and nacelles from the HS-125 flight test program, combined with a simulated HS-125 fuselage were windtunnel tested. Both propulsion and acoustic data were recorded. Preliminary thrust data results from the wind tunnel tests are summarized and compared to other mechanical suppressor test results. The test results indicate that a noise reduction of at least 16 EPNdB would be possible for the suppressor/ejector nozzle scaled to typical AST engine size with a 5% thrust loss at a typical takeoff climb speed

Social Support Seeking And Early Adolescent Depression And Anxiety Symptoms: The Moderating Role Of Rumination

This study examined how social support seeking and rumination interacted to predict depression and anxiety symptoms 6 months later in early adolescents (N = 118; 11-14 years at baseline). We expected social support seeking would be more helpful for adolescents engaging in low rather than high levels of rumination. Adolescents self-reported on all measures at baseline, and on depression and anxiety symptoms 6 months later. Social support seeking predicted fewer symptoms of depression and anxiety at low rumination levels but was not associated with benefits as rumination increased. For depression symptoms, social support seeking predicted more symptoms at high rumination levels. Results were stronger for emotion-focused than problem-focused support seeking and for depression compared with anxiety symptoms. These findings suggest that cognitive risk factors like rumination may explain some inconsistencies in previous social support literature, and highlight the importance of a nuanced approach to studying social support seeking

An analysis of the feasibility of using image processing to estimate the live weight of sheep

One of the difficulties in successfully managing the supply and use of animal feed in sheep farming is in knowing the live weight of the sheep in the various mobs a farmer may be using. Most farmers make intuitive estimates of whether their sheep are increasing, maintaining or losing weight. A few farmers will weigh samples from the mobs, but this is an expensive and tedious operation, and consequently not carried out very often. If an inexpensive and simple method could be devised for quickly obtaining the average live weight of a mob of sheep this would markedly aid their successful management. This discussion paper contains outlines of the various methods that might be used as well as the problems with each method. There are also discussions covering the efforts made, as explained in the literature, for use in estimating the live weight of other species. This provides a means of generating ideas. The discussion paper concludes with recommendations on what appear to be the most promising approaches that might be further investigated. If such a system could be devised there is no doubt many farmers around the world would utilise it to assist in the management of their feed supplies, and consequently improve the efficient production of meat and wool

The Rising Light Curves of Type Ia Supernovae

We present an analysis of the early, rising light curves of 18 Type Ia supernovae (SNe Ia) discovered by the Palomar Transient Factory (PTF) and the La Silla-QUEST variability survey (LSQ). We fit these early data flux using a simple power-law $(f(t) = {\alpha\times t^n})$ to determine the time of first light $({t_0})$, and hence the rise-time $({t_{rise}})$ from first light to peak luminosity, and the exponent of the power-law rise ($n$). We find a mean uncorrected rise time of $18.98 {\pm} 0.54$ days, with individual SN rise-times ranging from $15.98$ to $24.7$ days. The exponent n shows significant departures from the simple 'fireball model' of $n = 2$ (or ${f(t) \propto t^2}$) usually assumed in the literature. With a mean value of $n = 2.44 {\pm} 0.13$, our data also show significant diversity from event to event. This deviation has implications for the distribution of 56Ni throughout the SN ejecta, with a higher index suggesting a lesser degree of 56Ni mixing. The range of n found also confirms that the 56Ni distribution is not standard throughout the population of SNe Ia, in agreement with earlier work measuring such abundances through spectral modelling. We also show that the duration of the very early light curve, before the luminosity has reached half of its maximal value, does not correlate with the light curve shape or stretch used to standardise SNe Ia in cosmological applications. This has implications for the cosmological fitting of SN Ia light curves.Comment: 19 pages, 19 figures, accepted for publication in MNRA

A content validity approach to creating an end-user computer skill assessment tool

Practical assessment instruments are commonly used in the workplace and educational environments to assess a person's level of digital literacy and end-user computer skill. However, it is often difficult to find statistical evidence of the actual validity of instruments being used. To ensure that the correct factors are being assessed for a particular purpose it is necessary to undertake some type of psychometric testing, and the first step is to study the content relevance of the measure. The purpose of this paper is to report on the rigorous judgment quantification process using panels of experts in order to establish inter-rater reliability and agreement in the development of end-user instruments developed to measure workplace skills using spreadsheet and word-processing applications

Are workplace end-user computing skills at a desirable level? A New Zealand perspective

End-user computing is part of many occupations. The most requested end-user computing skills are experience with word-processing and spreadsheet applications. Often an employee’s skill level may not be good enough to be deemed effective. Frequently this occurs because employers expect that employees will have the requisite skill level without formally assessing this. This paper presents a study involving the testing of people who, in their jobs, use word-processing and spreadsheet software. Two instruments were created to assess skill in common work place computing tasks. The results showed that the majority of participants could only manage very basic spreadsheet tasks, even though the use of spreadsheets was part of their employment. Results for word-processing skill was more positive, with most participants completing all of the basic and some moderately advanced tasks. These results confirm that end-user computer skill, while required, is not at a level that could be deemed proficient

Prospective Genetic Screening Decreases the Incidence of Abacavir Hypersensitivity Reactions in the Western Australian HIV Cohort Study

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipient